Program |
4th Symposium of the André-Delambre Foundation
Amyotrophic Lateral Sclerosis: Causes and Therapeutic Perspectives |
 Thursday 25 September 2008
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| 8:30-8:40 |
Introduction and Welcome |
Human Genetics and Pathology
Chair: Jean-Pierre Julien |
| 8:40-9:10 |
Robert Brown (Massachusetts General Hospital)
ALS: Recent Insights from Genetics |
| 9:10–9:40 |
Peter Andersen (Umeå University, Sweden)
Clinical aspects of ALS associated with mutations in the SOD1 gene |
| 9:40-10:10 |
Guy Rouleau (Université de Montréal)
Genetics of ALS: recent developments |
| 10:10-10:30 |
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Model systems |
| 10:30-11:00 |
Michael Strong (University of Western Ontario)
TDP-43 in ALS: Don't shoot the messenger RNA binding protein |
| 11:00-11:30 |
Christopher Henderson (Columbia University)
Toward a cellular model of sporadic ALS |
| 11:30-12:00 |
Robert Brownstone (Dalhousie University)
Spinal regulation of motor neuron excitability |
| 12:00-1:30 |
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Toxic pathways
Chair: Denise Figlewicz (ALS Society of Canada) |
| 13:30-14:00 |
David Borchelt (McKnight Brain Institute, Florida)
Misfolding and aggregation of SOD1 in familial ALS |
| 14:00-14:30 |
Viji Ravindranath (National Brain Research Centre, India)
Redox driven activation of cell specific signalling pathways in neurodegeneration |
| 14:30-15:00 |
Christopher Shaw (University of British Columbia)
Steryls and steryl glucosides as causal factors in ALS and the interaction with genetic susceptiblity |
| 15:00-15:30 |
Refreshment break |
Disease Mechanisms |
| 15:30-16:00 |
Janice Robertson (University of Toronto)
Alternative splicing in ALS |
| 16:00-16:30 |
Jasna Kriz (Centre de recherche du CHUQ, Université Laval)
Real time imaging of ALS pathogenesis in mice |
| 16:30-18:00 |
Cocktail and poster session |
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Friday 26 September 2008 |
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Disease Mechanisms
Chair:
Heather Durham (Montreal Neurological Institute, McGill University) |
| 8:30 - 9:00 |
Don Cleveland (University of California at San Diego)
Non-cell autonomous determinants of disease in ALS |
| 9:00 - 9:30 |
Jeff Rothstein (Johns Hopkins School of Medicine)
Dysfunction of Astroglial-Neuronal Interactions in ALS- A mechanism for Disease propagation |
| 9:30 - 10:00 |
Jean-Philippe Loeffler (University of Strasbourg)
Lipid metabolism and energy homeostasis in ALS |
| 10:00 - 10:30 |
Refreshment break |
Immunity |
| 10:30 – 11:00 |
Michal Schwartz (The Weizmann Institute of Science, Israel)
Harnessing peripheral immune cells is needed for fighting off neurodegenerative diseases: Implications to ALS |
| 11:00 – 11:30 |
Charles Krieger (Simon Fraser University, Vancouver)
Bone marrow-derived monocytic cells in a murine model of ALS |
| 11:30 – 12:00 |
Jean-Pierre Julien (Centre de recherche du CHUQ, Université Laval)
Immunotherapy for ALS |
| 12:00 - 13:00 |
Lunch and poster session |
Stem Cells
Angela Genge (Montreal Neurological Institute, McGill University) |
| 13:00 - 13:30 |
Jeffrey D. Macklis (Harvard Medical School)
Molecular Development and Cellular Repair of Corticospinal Motor Neuron Circuitry |
| 13:30 - 14:00 |
Victor Rafuse (Dalhousie University)
Embryonic Stem Cell-Derived Motoneurons: A Tool for Studying ALS |
| 14:00 - 14:30 |
Clive Svendsen (University of Wisconsin)
Modeling and treating motor neuron diseases with stem cells |
| 14:30 - 15:00 |
Refreshment break |
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Preclinical and clinical studies |
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| 15:00 - 15:30 |
Francesco Fornai (University of Pisa)
Autophagy in ALS from basic findings to clinical implications |
| 15:30 - 16:00 |
Merit Cudkowicz (Massachusetts General Hospital)
Advances in ALS Therapy: A Brave New World |
| 16:00 |
Closing comments |
